Cinnamic acid: loose bones and comfortable life!

Hey, that is, the cramps in the colloquial language. When the cramps come, they often have great pain, muscle stiffness can not be their own, in many cases is very likely to endanger their lives! Skeletal tendons are often non-monitoring. Generally, you can use your hand to massage and return to normal. However, it is difficult for you to recover from your illness. You need to rely on medicines for conditioning.

At present, there are several kinds of bone loosening drugs on the domestic market, and some of them have good results. However, most of them have side effects such as irreversible damage to the nervous system. Recently, an antispasmodic drug using cinnamic acid as a main ingredient has been invented. It is a skeletal muscle relaxant and sedative that acts on the spinal cord.

The agent inhibits the release of excitatory amino acids such as glutamic acid and aspartic acid by agonism of the GABAβ-receptor, thereby inhibiting the transmission of single synapse and polysynaptic reflexes in the spinal cord and exerting an antispasmodic action. It can be used to relieve skeletal muscle spasm caused by many diseases, such as multiple sclerosis, syringomyelia, spinal cord tumor, transverse myelitis, spinal cord injury and motor neuron disease.

According to experts, the agent is rapidly and completely absorbed in the gastrointestinal tract. After a single oral dose of 10, 20, and 30 mg, 0.5 to 1.5 hours, the peak plasma concentrations were approximately 180, 340, and 650 μg/ml, respectively. The area under the corresponding blood drug concentration curve (AUCS) increased proportionally to the dose, with values ​​of 1140, 2350, and 3350 μg•h/ml, respectively. The concentration of active substance in cerebrospinal fluid was approximately 8.5 times lower than that in plasma, and plasma elimination half-life averaged 3 ~ 4 hours. The serum protein binding rate is about 30%.

Research and development staff said that within 72 hours, about 75% of the intake of the agent was excreted by the kidney, and about 5% of the metabolites were consumed. The rest of the intake, including 5% of the metabolites excreted from the feces, is a good skeletal muscle relaxant. In addition, the agent can improve nerve conduction and accelerate the regeneration of damaged nerves.

Cinnamic acid itself is a flavor and fragrance, without any toxic side effects on the human body.